{"id":3105,"date":"2024-04-16T12:55:13","date_gmt":"2024-04-16T15:55:13","guid":{"rendered":"https:\/\/www.medicina.ufmg.br\/sismid\/?p=3105"},"modified":"2024-04-16T12:55:13","modified_gmt":"2024-04-16T15:55:13","slug":"increased-cocaine-induced-conditioned-place-preference-during-periadolescence-in-maternally-separated-male-balb-c-mice-the-role-of-cortical-bdnf-microrna-212-and-mecp2","status":"publish","type":"post","link":"https:\/\/www.medicina.ufmg.br\/sismid\/2024\/04\/16\/increased-cocaine-induced-conditioned-place-preference-during-periadolescence-in-maternally-separated-male-balb-c-mice-the-role-of-cortical-bdnf-microrna-212-and-mecp2\/","title":{"rendered":"Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB\/c mice: the role of cortical BDNF, microRNA-212, and MeCP2."},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Rationale<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Early life stress is a major risk factor for cocaine addiction; however, the underlying molecular mechanisms remain relatively unexplored. MicroRNA-212 (miR-212) and methyl CpG binding protein 2 (MeCP2) have recently emerged as key regulators of brain-derived neurotrophic factor (BDNF) signaling during the acquisition and maintenance of cocaine-seeking behaviors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Objectives<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We therefore investigated the effect of maternal separation (MS) on cocaine-induced conditioned place preference (CPP) during periadolescence and how this influences miR-212, Mecp2, and Bdnf expressions in the prefrontal cortex.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-white-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s00213-016-4373-z\" style=\"background-color:#1a5491\">Acessar<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Rationale Early life stress is a major risk factor for cocaine addiction; however, the underlying molecular mechanisms remain relatively unexplored. MicroRNA-212 (miR-212) and methyl CpG binding protein 2 (MeCP2) have recently emerged as key regulators of brain-derived neurotrophic factor (BDNF) signaling during the acquisition and maintenance of cocaine-seeking behaviors. Objectives We therefore investigated the effect [&hellip;]<\/p>\n","protected":false},"author":111,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[122,160,200,233,234,232],"class_list":["post-3105","post","type-post","status-publish","format-standard","hentry","category-ciencia","tag-cocaina-3","tag-dependencia-de-crack-cocaina","tag-dependencia-quimica","tag-maes","tag-maternidade","tag-separacao-materna","entry"],"_links":{"self":[{"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/posts\/3105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/users\/111"}],"replies":[{"embeddable":true,"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/comments?post=3105"}],"version-history":[{"count":1,"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/posts\/3105\/revisions"}],"predecessor-version":[{"id":3106,"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/posts\/3105\/revisions\/3106"}],"wp:attachment":[{"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/media?parent=3105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/categories?post=3105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.medicina.ufmg.br\/sismid\/wp-json\/wp\/v2\/tags?post=3105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}