{"id":3246,"date":"2024-04-18T15:52:31","date_gmt":"2024-04-18T18:52:31","guid":{"rendered":"https:\/\/www.medicina.ufmg.br\/sismid\/?p=3246"},"modified":"2024-04-18T15:52:31","modified_gmt":"2024-04-18T18:52:31","slug":"cocaine-use-disorder-and-childhood-maltreatment-are-associated-with-the-activation-of-neutrophils-and-increased-inflammation","status":"publish","type":"post","link":"https:\/\/www.medicina.ufmg.br\/sismid\/2024\/04\/18\/cocaine-use-disorder-and-childhood-maltreatment-are-associated-with-the-activation-of-neutrophils-and-increased-inflammation\/","title":{"rendered":"Cocaine-use disorder and childhood maltreatment are associated with the activation of neutrophils and increased inflammation"},"content":{"rendered":"\n<p>Cocaine-use disorder (CUD) has been associated with early life adversity and activated cellular immune responses. Women are most vulnerable to complications from chronic substance disorders, generally presenting an intense feeling of abstinence and consuming significant drug amounts. Here, we investigated neutrophil functional activities in CUD, including the formation of neutrophil extracellular traps (NETs) and related intracellular signalling. We also investigated the role of early life stress in inflammatory profiles.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-1 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-white-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.cambridge.org\/core\/journals\/acta-neuropsychiatrica\/article\/abs\/cocaineuse-disorder-and-childhood-maltreatment-are-associated-with-the-activation-of-neutrophils-and-increased-inflammation\/E7C1534F8FBD19CF117ABDF57DAF50FE\" style=\"background-color:#1a5491\">Acessar<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cocaine-use disorder (CUD) has been associated with early life adversity and activated cellular immune responses. Women are most vulnerable to complications from chronic substance disorders, generally presenting an intense feeling of abstinence and consuming significant drug amounts. Here, we investigated neutrophil functional activities in CUD, including the formation of neutrophil extracellular traps (NETs) and related 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